SPECIALTY TECHNOLOGY

SPECIALTY
TECHNOLOGY

We have various skills and technologies accumulated in years of experiences of manufacturing APIs and intermediates. Furthermore, we never get content with the status quo and keep innovating new synthetic technologies. In recent years, we developed and commercialized the following special synthesis technologies.

Carbonylative Cross Coupling

The carbonylative cross coupling is an effective method which enables a direct synthesis of amides or esters from halogenated aromatic compounds. We provide the industrial scale manufacturing although it needs harmful carbon monoxide.

Mitsunobu Reaction

The Mitsunobu reaction is an effective method which brings alcohol to an inversion of stereochemistry. This reaction also enables synthesis of phenyl ethers and alkylation of pyrroles.

Synthesis of aminopyridine derivatives

Aminopyridine is the key scaffold for pharmaceuticals. We have developed our original method which converts bromo aminopyridine to various derivatives in one-pot.
This method is applicable not only to aminopyridine but also to aniline and heteroaromatic compounds having amino groups. Please contact us for more information.

THE SYNTHESIZABLE COMPOUNDS

  R1 R2 R3 CAS
Alkyl Ethyl H H 33252-32-3
Alkyl nPropyl H H 61702-15-6
Alkyl iPropyl H H 149489-07-6
Alkyl nButyl H H 847461-35-2
Alkyl secButyl H H 61702-16-7
Alkyl PhCH2 H H 91391-85-4
Alkyl Ph(CH2)2 H H 96428-84-1
Alkyl H Methyl H 1603-41-4
Alkyl H Ethyl H 19842-07-0
Alkyl H nPropyl H 92410-92-9
Alkyl H iiPropyl H 603310-75-4
Alkyl H nButy1 H 69372-01-6
Alkyl H nPentyl H 60781-86-4
Alkyl H PhCH2 H 98477-40-8
Alkyl H Ph(CH2)2 H 54768-59-1
Alkyl H HOOC-CH2 H 39658-45-2
Alkyl H MeOOC-CH2 H 174891-02-2
Alkyl H EtOOC-CH2 H 1174229-72-1
Alkyl H MeOOC-(CH2)2 H 446263-95-2
Alkyl H EtOOC-(CH2)2 H 666721-07-9
Alkyl H H Ethyl 21717-29-3
Alkyl H H nPropyl 41995-29-3
Alkyl H H iPropyl 78177-12-5
Alkyl H H nButyl 95337-74-9
Alkyl H H nPentyl 99167-14-3
Alkyl H H PhCH2 57963-09-4
Alkyl H H Ph(CH2)2 85230-39-3
Alkyl H H HOOC-CH2 339195-51-6
Alkyl H H EtOOC-CH2 71469-82-4
Alkyl H H HOOC-(CH2)2 153140-16-0
Alkyl H H HOOC-(CH2)3 165105-45-3
Alkyl H H NC-(CH2)2 153140-17-1
Alcohol HOCH(Me) H H 885266-91-1
Alcohol HOCH(Ph) H H 906070-01-7
Alcohol HOC(Me)2 H H 1229649-59-5
Alcohol HOC(Ph)2 H H -
Alcohol HOC(Me)(Ph)CH2 H H 1375501-24-8
Alcohol H HOC(Me)2 H 843643-03-8
Alcohol H HOCH(Me) H 1335054-83-5
Alcohol H HOCH(Pr) H 856957-50-1
Alcohol H HOCH(Ph) H 1355229-59-2
Alcohol H HOC(Me)(Bu) H 843643-06-1
Alcohol H HOC(Me)(CF3) H 1507759-10-5
Alcohol H HOC(CF3)2 H 625838-00-8
Alcohol H 1-HO-cyclopenan-1-yl H 1500761-69-2
Alcohol H HO(CH2)2 H 1314973-84-6
Alcohol H H HOCH(Me) 146859-53-2
Alcohol H H HOCH(Et) 954225-31-1
Alcohol H H HOC(Me)2 1446793-28-7
Alcohol H H HO(CH2)2 101012-00-4
Carbonyl MeCO H H 42182-25-2
Carbonyl H MeCO H 19828-20-7
Carbonyl H nPrCO H 1407884-26-7
Carbonyl H PrCO H 53439-80-8
Carbonyl H H MeCO 1060801-23-1
Ester MeOOC H H 6937-03-7
Ester EtOOC H H 13362-30-6
Ester H MeOOC H 36052-24-1
Ester H EtOOC H 39658-41-8
Ester H iPrOOC H 827588-24-9
Ester H tBuOOC H 69879-20-5
Ester H PhCH2OOC H 935687-49-3
Ester H H MeOOC 36052-26-3
Ester H H EtOOC 69142-64-9
Ester H H PhCH2OOC 443685-91-4
  R1 R2 R3 CAS
Alkyl nPropyl H H 188670-06-6
Alkyl HOOC-CH2 H H 80352-63-2
Alkyl NC-(CH2)3 H H 84604-29-5
Alkyl H H Ethyl 126553-00-2
Alkyl H H nPropyl 217302-91-5
Alkyl H H nButyl 30683-12-6
Alkyl H H nPentyl 99568-10-2
Alkyl H H nHexyl 1384194-15-3
Alkyl H H nOctyl 143807-47-0
Alkyl H H PhCH2 40296-80-8
Alkyl H H Ph(CH2)2 203663-96-1
Alkyl H H HOOC-CH2 415912-76-4
Alkyl H H MeOOC-CH2 174891-11-3
Alkyl H H EtOOC-CH2 174890-58-5
Alkyl H H HOOC-(CH2)2 119711-31-8
Alkyl H H MeOOC-(CH2)3 119711-19-2
Alkyl H H NC-CH2 883993-15-5
Alcohol HOC(Me)2 H H 899438-57-4
Alcohol H H HOC(Me)2 1893405-53-2
Alcohol H H HOC(CF3)2 900802-97-3
Alcohol H H HO(CH2)2 1552277-17-4
Carbonyl MeCO H H 13210-25-8
Carbonyl PhCO H H 3810-13-7
Carbonyl H H MeCO 51460-32-3
Carbonyl H H PhCO 53439-82-0
Carbonyl H H EtCO 1412357-21-1
Ester H MeOOC H 36052-25-2
Ester H EtOOC H 17285-76-6
Ester H H MeOOC 67515-76-8
Ester H H EtOOC 119830-47-6
Ester H H tBuOOC 1512138-42-9
Ester H H PhCH2OOC 1531760-67-4

  • PHARMACEUTICAL
    BUSINESS

    We provide process development, method development and validation, and manufacturing services for intermediates and APIs (Active Pharmaceutical Ingredients), which have been developed by pharmaceutical companies, academia, and venture companies. Our clients can rely on our superior technologies and quality assurance system which have been developed over many years of experience in the industry.

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  • COSMETIC
    BUSINESS

    We offer sourcing, contract manufacturing and sales services of cosmetic chemicals to send beauty and moisture to customers around the world.

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  • CHEMICAL
    BUSINESS

    We supply high quality raw materials for chemicals from companies inside and outside of Japan leveraging our technologies and supply network.

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